Advances in Radiation Oncology in Lung Cancer

Editorial Reviews
Book Description
Although decades of laboratory and clinical research have led to incremental improvement in treatment outcome, lung cancer remains one of the most deadly diseases. This volume is unique in being devoted solely to the radiation oncology of lung cancer, and will be of great value to all who are involved in the diagnosis and treatment of the disease. Both non-small cell and small cell lung cancer are considered in detail. Current state-of-the-art treatment strategies and novel approaches that promise further improvements in outcome are explained and evaluated, with the aid of high-quality illustrations. Treatment-related toxicity is discussed, and further individual chapters focus on topics such as quality of life studies, prognostic factors and pitfalls in the design and analysis of clinical trials.

1 Pretreatment Considerations. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1
1.1 Molecular Biology and Genetics of Lung Cancer
1.2 Angiogenesis in Lung Cancer
1.3 Contemporary Issues in Staging of Lung Cancer
2 Basic Treatment Considerations . . . . . . . . . . . . . .
2.1 Lung Cancer Surgery
2.2 Radiation Therapy
2.2.1 Radiobiology of Normal Lung Tissue and Lung Tumours
2.2.2 Radiation Time, Dose, and Fractionation in the Treatment of Lung Cancer
2.2.3 Treatment Planning and Conformal Radiotherapy
2.2.4 Target Volumes in Non-Small Cell Lung Cancer
2.2.5 Target Volumes in Small Cell Lung Cancer
2.2.6 Radioprotectors and Chemoprotectors in the Management of Lung Cancer
2.3 Lung Cancer Chemotherapy for Radiation Oncologists
2.4 Radiotherapy and Chemotherapy – Fundamentals and Preclinical Data
3 Current Treatment Strategies in Non-Small Cell Lung Cancer
3.1 Early Stage in Non-Small Cell Lung Cancer
3.1.1 Radiotherapy in Early Stage Non-Small Cell Lung Cancer
3.1.2 Postoperative Radiotherapy for Non-Small Cell Lung Carcinoma
3.1.3 Photodynamic Therapy
3.2 Locally Advanced Non-Small Cell Lung Cancer
3.2.1 Radiochemotherapy in Locally Advanced Non-Small Cell Lung Cancer
3.2.2 Chemotherapy or Chemoradiotherapy Followed by
Surgical Resection for Non-Small Cell Lung Cancer
3.2.3 Palliative External Beam Thoracic Radiotherapy
3.2.4 Intraoperative Electron Beam Radiotherapy in Lung Cancer
3.2.5 Intraluminal Radiotherapy
4 Treatment of Small-Cell Lung Cancer
4.1 Limited Disease of Small-Cell Lung Cancer
4.2 Prophylactic Cranial Irradiation in Small-Cell Lung Cancer
5 Radiation Therapy for Recurrent Lung Cancer
6 Radiotherapy of Lung Cancer in Elderly Patient
7 Advances in Supportive and Palliative Care for Lung Cancer Patients
8 Treatment-Related Toxicity
8.1 Hematological Toxicity in Lung Cancer
8.2 Radiation-Induced Lung and Heart Toxicity
Timothy D. Shafman, Xiaoli Yu, Zjelko Vujaskovic, Mitchell
Anscher, Keith Miller, Robert Prosnitz, and Lawrence B. Marks . . 351
8.3 Spinal Cord
8.4 Radiation Therapyy-Related Toxicity: Esophagus
8.5 Brain
9 Quality of Life in Radiation Oncology of Lung Cancer
10 Prognostic Factors in Lung Cancer
11 Future Strategies in Lung Cancer
11.1 Intensity-Modulated Radiation Therapy for Lung Cancer
11.2 Stereotactic Radiotherapy and Gated Therapy
11.3 Novel Substances in the Treatment of Lung Cancer for
Radiation Oncologists
11.4 PET Scanning in Staging and Evaluation of Response to Treatment of Lung Cancer
11.5 Heavy Particles in Lung Cancer
11.6 Translational Research in Radiation Oncology of Lung Cancer
12 Pitfalls in the Design, Conduct and Analysis of Randomised Clinical Trials
13. New Directions in the Evaluation and Presentation of Clinical Research in Lung Cancer
Subject Index
List of Contributors page 517

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